Can You Donate Plasma If You Smoke Weed? Get Facts Here! The Sanctuary Can you donate blood if you smoke? Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. E cigarettes and vapes YES, you can donate blood if you smoke or consume cannabis. Let's break the stigma! All donors go through the same health screening. All blood donations are tested for several types Driving After Taking Any Form of Marijuana Is Unsafe