Does Saliva Kill Sperm: Trying to Get Pregnant Fertility Lubricant: Safe Use When Trying to Conceive Using spit as lube? Heres why you *shouldnt*: It dries up fastterrible lubrication. Spreads infections (yep, even cold sores). Enzymes in saliva can mess with your vaginal microbiome. So TTC tip: skip regular lube (and saliva). Power Play Lube mimics fertile cervical mucus to help your swimmers reach the egg while keeping intimacy comfortable. Try it before its gone! The Bird & Lubricant that is helpful for sperm Mayo Clinic Health System When trying to conceive, choosing the right lubricant matters. Some common products like oil based lubricants, petroleum jelly, saliva, and regular lubricants may harm sperm and reduce fertility chances. Instead, opt for fertility friendly,