A Pelvic Floor PTs Guide to Choosing the Right Lubricant Silicone vs Water Based Lube: Which is Right for You? [Pros and Cons] ByQuanna Silicone vs Water Based Lube: Which Should You Use and When? The main difference between silicone based and water based foundations is their primary ingredient, which affects their texture, finish, and how they interact with different skin types. Silicone Based Foundation Main Ingredients: Contains silicones Differences Between Water Based and Silicone Based Lubricants Types of Lube Explained: Water,Silicone, Aloe Promescent